Effect of mild hypothermia on serum level of MMP-9, intracranial pressure and cerebral blood flow dynamics in patients with severe craniocerebral injury
REN Zhi-wen
ZHAO Dong
LIU Qi
WANG Hui
WANG Ye-zhong
Abstract：Objective To investigate the clinical effect of mild hypothermia treatment (MHT) on the patients with severe craniocerebral injury and its mechanism. Methods Fifty patients with severe craniocerebral injury treated in our hospital from January, 2013 to April, 2014 were randomly divided into two groups of 50 patients each, i.e. control group, in which the patients were treated by standard large trauma craniotomy and conventional therapy, and observed group, in which the patients were treated by the mild hypothermia from 1 to 3 hours after the craniotomy beside the standard large trauma craniotomy and conventional therapy. The serum level of matrix metalloproteinase-9 (MMP-9), intracranial pressure (ICP) and cerebral blood flow dynamics were determined in 2 groups and compared each other. Results The serum level of MMP-9 and ICP were significantly lower in the observed group than those in control group from 3 to 7 days after the treatment (P<0.05). The systolic and mean velocities of blood flow of middle cerebral artery were significantly higher in the observed group than those in control group (P<0.05) and its pulse index was significantly lower in the observed group than that in control group (P<0.05). Conclusion MHT can effectively lower the serum level of MMP-9 and ICP and improve the cerebral blood flow dynamics in the patients with severe craniocerebral injury.
Keywords：Mild hypothermia treatmentSevere craniocerebral injuryMMP-9Intracranial pressureCerebral blood flow dynamics
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 398-400 )