Endoscopic surgery and microsurgery for pituitary adenomas:a Meta analysis
ZHANG Wen-hua
XIE Meng
WANG Xuan
LIN Min-hua
Abstract：Objective To compare the safety of endoscopic surgery and its effect on pituitary adenomas with microsurgery. Methods The databases including Pubmed, EMbase, CBM, CNKI, VIP and Wanfang were searched by the computer from the time of the databases establishment to May 31, 2014 for collecting the randomized control trials and case control studies about the endoscopic surgery vs microsurgery for the pituitary adenomas. Meta analyses of the data derived from the databases which had been selected and assessed respectively by two reviewers were performed by the RevMan 5.2 software. Results Eight studies involving 712 patients were included in the present study. The comprehensive results showed by Meta analysis were as follows. There were significant differences in the occurrent rate of epistaxis [OR=0.24, 95% CI (0.07~0.78), P=0.02] and postoperative hospital stay (P<0.05) between both the patients undergoing endoscopic surgery and ones undergoing microsurgery, between which there were insignificant differences in the rate of the total removal of the adenomas [OR=1.23, 95%CI (0.62~2.46), P=0.56], postoperative recovery of hormone level [OR=1.21, 95%CI (0.58~2.55), P=0.61], cerebraospinal fluid rhinorrhea [OR=1.44, 95%CI (0.80~2.58), P=0.23], diabetes insipidus [OR=1.17, 95%CI (0.71~1.94), P=0.53], meningitis/encephalitis [OR=1.15, 95% CI (0.38~3.48), P=0.81], and duration of the operation (P>0.05). Conclusions The endoscopic surgery may reduce the occurrent rate of the epistaxis and shorten hospital stay compared to the microsurgery in the patients with pituitary adenomas.
Keywords：Pituitary adenomaEndoscopic surgeryMicrosurgeryCurative effectSafetyMeta analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 78-80 )