MRI characteristics of pituitary adenomas and relationships among the adenomas volume, serum GH levels and pathological immune responses in patients with acromegaly
KONG Ling-sheng
YAO Wei-cheng
LI Shi-fang
HE Zhao-zhong
CHENG Lei
Abstract：Objective To explore the MRI characteristics of the pituitary adenomas and relationships among the adenomas volume, basic serum growth hormone (GH) level, pathological immune responses in the patients with acromegaly. Methods The clinical data of 84 acromegaly patients with pituitary adenomas, who underwent microsurgery via single-nostril transspheniodal approach from January, 2008 to June, 2013, were analyzed retrospectively. Results MRI showed that some tumors broke the sellar diaphragm into suprasellar regions or the sellar floor into the sphenoid sinuses. Infrasellar invasion index [(2.35±0.69) cm] was significantly higher than that [(0.66 ± 0.25) cm] of suprasellar invasion index (P<0.01). There was no significant correlation among the preoperative basic serum GH level, tumor volume and GH immune response strength (optical density value) (P>0.05). Conclusions The pituitary adenomas volumes are insignificantly related to the preoperative basic serum GH level, and GH pathological immune response strength in the patients with cromegaly, in whom the pituitary adenomas trends to growth into the sphenoid sinuses.
Keywords：AcromegalyPituitary adenomaGrowth hormoneImmune responseMRI characteristics
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 516-518 )