Depression in Parkinson's disease and its association with cognition,balance and quality of life
ZHANG Liyin
Abstract：Objective To explore the impact of depressive state on cognitive function,sleep quality,balance function and quality of life in hospitalized Parkinson's disease patients.Methods A total of 55 inpatients with Parkinson's disease were recruited from Sichuan Bayi Rehabilitation Center be-tween January,2023 and May,2025.Based on the scores of Hamilton Depression Scale(HAMD),they were di-vided into depressive group(n=39)and non-depressive group(n=16).The depressive group was further subdi-vided into mild cognitive impairment(MCI)subgroup(n=13)and moderate-to-severe cognitive impairment sub-group(n=26)according to the scores of Montreal Cognitive Assessment(MoCA).The Pittsburgh Sleep Quality Index(PSQI),Berg Balance Scale(BBS),modified Rivermead Mobility Index(MRMI),and 36-Item Short Form Survey(SF-36)were used to evaluate functional performance across various dimensions.Results The PSQI score was higher in the depressive group than in the non-depressive group(β=-0.341,P<0.001),while the scores for physical component summary-related dimensions(physical function,role physical and gener-al health)and mental component summary-related dimensions(vitality and social function)of SF-36 were lower(β>0.279,P<0.05).The HAMD score of the depressive group was correlated with PSQI scores and most SF-36 dimension scores(|r|>0.329,P<0.05).The BBS score was lower in the moderate-to-severe cognitive impair-ment subgroup than in the mild cognitive impairment subgroup(F=9.224,P=0.004).Conclusion Depression is closely associated with impairment in sleep,balance function and quality of life in Parkinson's disease patients.
Keywords：Parkinson's diseasedepressioncognitionbalancequality of life
Publication Date：2026-02-25
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：7( 174-180 )