Association between gastrointestinal diseases and dementia:an analysis based on CHARLS database
HUANG Maomao
XING Fei
LI Dan
WANG Jianxiong
Abstract：Objective To explore the association between gastrointestinal diseases and dementia among older adults in China.
Methods Data were extracted from the 2018 China Health and Retirement Longitudinal Study(CHARLS).Adults aged≥60 years with complete key data were included.
Results A total of 6 186 older adults were enrolled,out of whom 32.15%with gastrointestinal diseases and 13.95%with dementia.There was a significant positive correlation between gastrointestinal diseases and dementia(OR=1.178,95%CI 1.001 to 1.384),and this association remained robust after adjusting for confounding factors.Strati-fied analysis showed that the correlation was significant in subgroups of females,urban dweller,primary school education level,history of smokers,no alcohol consumption,individuals with two or more chronic conditions,and those with depressive symptoms.Stratification by age,sleep duration and physical activity metabolism did not significantly alter the association between gastrointestinal diseases and dementia.
Conclusion Strengthening the prevention,treatment and management of gastrointestinal diseases in older adults in Chi-na may help reduce the risk of dementia.
Keywords：gastrointestinal diseasesdementiacross-sectional studyChina Health and Retirement Longitudinal Study
Publication Date：2025-12-25
Online Publishing Date：2026-01-06(First online date of this platform, not the publication date of the document)
Pages：8( 1456-1463 )