Effect of computerized cognitive remediation therapy on post-stroke cognitive impairment

YAN Ruxiu; SONG Luping; HUANG Fubiao; LIANG Yanhua; CUI Yao; YANG Hao

doi:10.3969/j.issn.1006-9771.2025.12.008

Abstract：Objective To observe the effect of computerized cognitive remediation therapy(CCRT)on cognitive function and activi-ties of daily living(ADL)in patients with post-stroke cognitive impairment(PSCI). Methods From November,2021 to May,2023,56 inpatients with PSCI in Beijing Bo'ai Hospital were recruited and ran-domly divided into control group(n=28)and experimental group(n=28).The control group received conven-tional cognitive training combined with occupational therapy cognitive training activities,while the experimental group received conventional cognitive training combined with CCRT,for four weeks.They were evaluated with Loewenstein Occupational Therapy Cognitive Assessment(LOTCA),Repeatable Battery for Assessment of Neu-ropsychological Status(rBANS)and modified Barthel Index(MBI)before and after treatment. Results Three cases dropped out in each group.After treatment,the total scores of LOTCA and rBANS,and the score of MBI increased significantly in both groups(|t|≥8.944,P<0.001).The differences in the scores of visuomotor organization and thinking operations domains in LOTCA between pre-treatment and post-treatment(|t|≥2.120,P<0.05),and the differences in the scores of immediate memory,speech function,attention and delayed memo-ry domains in rBANS between pre-treatment and post-treatment(|t|≥2.392,P<0.05)were higher in the experi-mental group than in the control group. Conclusion CCRT can effectively improve the overall cognitive function and ADL of PSCI patients.Compared with oc-cupational therapy cognitive training activities,CCRT demonstrates superior efficacy on aspects such as visuomo-tor organization,thinking operations,immediate memory,speech function,attention and delayed memory do-mains.