Motor-cognitive dual-task training for cognitive function in patients with Parkinson's disease:a meta-analysis

ZHU Airong; LIU Peihao; GUO Jing; GUAN Tingyu; CHEN Xizhu; CAI Shining; HU Yan; ZHANG Yuxia

doi:10.3969/j.issn.1006-9771.2025.12.002

Abstract：Objective To explore the effect of motor-cognitive dual-task training on cognitive function in patients with Parkinson's disease(PD). Methods Following the PRISMA guidelines,randomized controlled trials(RCT)evaluating the effect of motor-cogni-tive dual-task training on cognitive function in PD patients were systematically searched in the Cochrane Library,Web of Science,Embase,PubMed,CNKI,Wanfang data,VIP and Chinese Biomedical Literature Database from inception to December 20,2024.The methodological quality of the included studies was assessed using the Co-chrane Handbook for Systematic Reviews of Interventions version 5.1.0 risk-of-bias tool and the PEDro scale.Meta-analysis was conducted using RevMan 5.4,and GRADE approach was applied to evaluate the quality of ev-idence. Result A total of ten studies involving 330 patients were included,with PEDro scores ranging from six to nine.Meta-analysis showed that motor-cognitive dual-task training significantly improved Montreal Cognitive Assessment(MoCA)scores(MD=2.05,95%CI 0.38 to 3.73,P=0.02).There was no difference in Stroop Color and Word Test(SCWT)(reaction time and accuracy),Trail Making Test A(TMT-A)and Trail Making Test B(TMT-B)from the control group(P>0.05).Subgroup analysis indicated that interventions lasting more than three months improved the MoCA scores(MD=3.64,95%CI 3.13 to 4.16,P<0.001).The GRADE rating of evidence was low for MoCA improvement,and moderate for improvements in TMT-A,TMT-B,and Stroop Color-Word Test(reaction time and accuracy). Conclusion Motor-cognitive dual-task training can improve overall cognitive function in patients with PD,as the inter-vention durations more than three months.The effect on visuospatial and executive function requires further in-vestigation.