Effect of functional electrical stimulation hand cycling on functional connection of brain networks in stroke pa-tients:a study based on functional near-infrared spectroscopy
XU Sheng
ZHANG Min
YANG Qingqing
WANG Qinglei
GENG Ayan
WANG Tong
GUO Chuan
Abstract：Objective To explore the potential central mechanisms of functional electrical stimulation(FES)hand cycling in promot-ing upper limb motor recovery after stroke.
Methods A total of 35 stroke patients hospitalized in the Rehabilitation Center of Changzhou De'an Hospital from May,2023 to December,2024 were enrolled.They sequentially completed 10-minute FES hand cycling and 10-minute sham stimulation(simple hand cycling)tasks.The task order was randomized via dice rolling.Functional near-in-frared spectroscopy(fNIRS)was used to monitor real-time cerebral hemodynamic changes during both tasks to calculate the overall functional connectivity(FC)strength and the FC strength within regions of interest.
Results The overall FC strength was higher during the FES hand cycling task than during the sham task(t=2.591,P<0.05),as well as FC between the ipsilateral primary motor cortex(iM1)and ipsilateral somatosensory association cortex(iSAC),iM1 and contralateral somatosensory association cortex(cSAC),ipsilateral pre-motor and supple-mentary motor cortex(iPMC)and iSAC,iPMC and cSAC,iPMC and ipsilateral primary somatosensory cortex(iS1),iPMC and iM1,and contralateral pre-motor and supplementary motor cortex(cPMC)and iSAC(PFDR<0.05).
Conclusion FES hand cycling can promote the cortical function remodeling between cerebral hemispheres and the af-fected hemisphere,to integrate sensory-motor function.
Keywords：strokeupper limbmotor functionfunctional electrical stimulation hand cyclingfunctional near-infrared spectroscopyfunctional connectioncortical function remodeling
Publication Date：2025-10-25
Online Publishing Date：2025-11-19(First online date of this platform, not the publication date of the document)
Pages：7( 1181-1187 )