Effect of time intervals of priming continuous theta burst stimulationon on cortical plasticity induced by intermit-tent theta burst stimulation
GENG Ayan
WANG Qinglei
SHEN Junfan
ZHU Shizhe
JI Panpan
WANG Tong
GUO Chuan
Abstract：Objective To investigate the effect of continuous theta burst stimulation-intermittent theta burst stimulation(cTBS-iT-BS)priming protocols with different time intervals on the plasticity of primary motor cortex(M1).
Methods A total of 39 healthy young adults were recruited from Changzhou De'an Hospital from March to August,2024.Participants received cTBS-iTBS priming protocols with intervals of 5 minutes,10 minutes and 15 minutes using a randomized crossover design.Motor-evoked potential(MEP)amplitudes in M1 were recorded at baseline(before intervention)and 0 minute,10 minutes,20 minutes and 30 minutes after intervention.
Results The main effects of stimulation protocol(F=19.761,P<0.001)and measurement time(F=10.224,P<0.001)were significant.At each time point after intervention,the MEP amplitude was significantly higher under the 10-minute interval than under the 5-minute and 15-minute intervals(t>3.010,P<0.05).
Conclusion The 10-minute interval of cTBS-iTBS is more effective on M1 plasticity.
Keywords：theta burst stimulationplasticitymotor-evoked potentialBienenstock-Cooper-Munro theory
Publication Date：2025-05-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 607-612 )