Effect of high-definition transcranial direct current stimulation combined with upper limb robot on upper limb dysfunction after ischemic stroke
WANG Xiaojun
WANG Hani
YU Hong
LI Yuanmei
ZHOU Yuda
Abstract：Objective To investigate the effect of high-definition transcranial direct current stimulation(HD-tDCS)combined with upper limb robot on upper limb dysfunction in patients with ischemic stroke.
Methods From January,2023 to March,2024,56 inpatients with upper limb dysfunction after ischemic stroke were se-lected from Zhejiang Rehabilitation Medical Center,and divided into control group(n=28)and experimental group(n=28)randomly.All the patients received comprehensive treatment and upper limb robot training,while the control group received sham HD-tDCS and the experimental group received HD-tDCS,for four weeks.They were assessed with Fugl-Meyer Assessment-Upper Extremities(FMA-UE),Wolf Motor Function Test(WMFT)and modified Barthel Index(MBI)before and after treatment.The cortical amplitude,cortical latency and central motor conduction time(CMCT)of transcranial magnetic stimulation motor-evoked potential(MEP)were record-ed,and a correlation analysis was conducted.
Results The scores of FMA-UE,WMFT and MBI,and MEP cortical amplitude,cortical latency and CMCT improved in both groups after treatment(t>3.177,P<0.01),and they were better in the experimental group than in the con-trol group(t>3.610,P<0.01).The scores of FMA-UE and WMFT negatively correlated with MEP cortical la-tency and CMCT,and positively correlated with MEP cortical amplitude(|r|>0.448,P<0.001).
Conclusion HD-tDCS is effective on upper limb motor function and activities of daily living for patients with ischemic stroke,and can improve corticospinal motor conduction.
Keywords：ischemic strokeupper limbhigh-definition transcranial direct currentrehabilitation robotmotor-evoked potential
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 218-224 )