Application of transcranial ultrasound stimulation in neurorehabilitation:a bibliometric analysis

HE Huifang; GONG Xiang; WANG Xihui; ZHU Sisi; SHEN Ying

doi:10.3969/j.issn.1006-9771.2024.12.007

Abstract：Objective To analyze the current status,research hotspots,and development trends of transcranial ultrasound stimulation(TUS)in neurorehabilitation. Methods Relevant literature on the application of TUS in neurological rehabilitation was retrieved from CNKI,Wanfang data,and Web of Science Core Collection,covering publications from inception to December 31,2023.VOS-viewer 1.6.20 and CiteSpace 6.2.R1 were used for visualized analysis. Results A total of 247 articles were included,with 124 in Chinese and 123 in English,showing an increasing trend in an-nual publications.The major contributors to English literature were China,the United States,Canada,France and South Korea.High-frequency Chinese keywords included transcranial ultrasound,neuromodulation,Parkinson's disease,stroke and clinical efficacy.The keyword clusters were transcranial ultrasound,neuromodulation,upper limb function and Parkinson's disease.Bursting keywords included rehabilitation,neural function,ultrasound therapy,closed-loop control and low intensity.High-frequency English keywords included focused ultrasound,deep brain stimulation,transcranial magnetic stimulation,blood-brain barrier and thalamotomy.Keyword clusters covered tissue plasminogen activator,ultrasonic imaging,transcranial magnetic stimulation,thalamotomy and ul-trasound.Bursting keywords featured essential tremor,neurostimulation,direct current stimulation and transcrani-al ultrasound stimulation. Conclusion Research on the application of TUS in neurorehabilitation is on the rise,focusing on its efficacy and safety in Parkinson's disease,essential tremor,and ischemic stroke.Future research needs to explore the mechanisms of TUS,optimize treatment plans,and promote the development of individualized therapies.