Mechanism of Nuclear Factor-κB in Skeletal Muscle Atrophy during Prevention and Treatment of Exercise in Pa-tients with Chronic Obstructive Pulmonary Disease (review)
WU Wei-bing
LIU Jing-xin
LIU Xiao-dan
WANG Zhen-wei
YAN Jun-tao
Abstract：Chronic obstructive pulmonary (COPD) has significant extra pulmonary effects, which could induce atrophy of peripheral skeletal muscle and respiratory muscles, and significantly influence the respiratory function and quality of life. Muscle nuclear factor (NF)-κB activation plays a key role in the skeletal muscle atrophy. This article discussed the potential mechanisms on how NF-κB signaling pathway increasing protein breakdown and reducing muscle regeneration. On this basis, we explored the role of NF-κB in skeletal muscle at-rophy in patients with COPD during exercise.
Keywords：chronic obstructive pulmonary diseaseskeletal muscle atrophyexercisenuclear factorκBreview
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1171-1174 )