Effects of Electro-acupuncture Pretreatment on Interleukin-1β, Interleukin-6 and Apoptosis in Rats after Cere-bral Ischemia-reperfusion Injury
ZHU Lu-wen
YE Tao
JIANG Yun-fei
WU Xiao-jun
LI Hong-yu
SONG Ming-yang
TANG Qiang
Abstract：Objective To investigate the effect of electro-acupuncture pretreatment on content of interleukin (IL)-1βand IL-6 in serum and ischemic penumbra, and apoptosis in ischemic penumbra in rats after cerebral ischemia-reperfusion injury. Methods Thirty-six male Sprague-Dawley rats were randomly divided into sham group (n=12), model group (n=12), and electro-acupuncture pretreatment group (n=12). The middle cerebral arteries were occluded for 120 minutes and reperfused. Twenty-four hours after reperfusion, the level of IL-1βand IL-6 in serum and brain tissue was detected with enzyme-linked immunosorbent, and apoptosis of ischemic penumbra was detected with TU-NEL. Results The content of IL-1βand IL-6 in the serum and brain tissue, and the number of TUNEL-positive cells decreased in the elec-tro-acupuncture pretreatment group compared with that in the model group (P<0.01). Conclusion Electro-acupuncture pretreatment may in-hibit inflammatory response and apoptosis in cerebral ischemia-reperfusion injury.
Keywords：cerebral ischemia-reperfusionelectro-acupuncturepretreatmentinterleukin-1βinterleukin-6inflammatory responseapoptosisrats
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 765-768 )