Role of Paired Immunoglobulin-like Receptor B in Nerve Regeneration (review)
XIAO Lan
WANG Yong-tang
WEI Jing-xiang
SHU Ya-hai
LU Xiu-min
YU Ying
Abstract：It is difficult for regeneration of central nervous system (CNS) in adult mammals, and myelin-associated inhibitors (MAIs) are believed to be major contributors. Paired immunoglobulin-like receptor B (PirB), as a co-receptor of MAIs, and expresses highly in CNS after injury, plays a vital role in the signal transduction of inhibition in the injured CNS. Knockout or block of PirB in vitro and in vivo may promote the neuro-regeneration after spinal cord injury or hypoxic-ischemic brain damage, release the damage induced byβ-amyloid in Al-zheimer's disease, recover the neural function in brain inflammation models, improve the reconstruction of vision after optic nerve injury, and so on. PirB may be a potential therapeutic target for neuro-regeneration and synaptic plasticity.
Keywords：paired immunoglobulin-like receptor Bmyelin-associated inhibitorsaxonal growthnerve regenerationreview
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 544-547 )