Effects of Guhong Injection on Expression of Vascular Endothelial Growth Factor in Cortex after Cerebral Isch-emia-reperfusion in Rats
ZHANG Rui
LIANG Zhen
YANG Nan
JI Chao
LIU Yan-yong
ZUO Ping-ping
Abstract：Objective To study the effects of Guhong injection on the expression of vascular endothelial growth factor (VEGF) in the cortex 14 days after cerebral ischemia-reperfusion. Methods 30 male Sprague-Dawley rats were divided into sham group (n=6), ischemia group (n=6), aceglutamide injection group (n=6), Honghua injection group (n=6) and Guhong injection group (n=6). The middle cerebral ar-teries of all the rats were occluded for 2 hours and reperfusion, except the sham group. Drugs were administered once a day 24 hours after re-perfusion. The expression of VEGF in cortex was detected with enzyme-linked immunosorbent assay (ELISA) 14 days after reperfusion. Re-sults The expression of VEGF decreased in the ischemia group compared with the sham group (P<0.001), and it increased both in the ace-glutamide and Guhong injection groups compared with the ischemia group (P<0.05). Conclusion Guhong injection can significantly in-crease the expression of VEGF in the cortex 14 days after ischemia-reperfusion, which may be one of the ways for neuro-protection.
Keywords：cerebral ischemia-reperfusionGuhong injectionvascular endothelial growth factorrats
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 770-772 )