Effect of Ginkgo Biloba Extract on Intestinal Function after Spinal Cord Injury in Rats
LI Xin-rui
LUO Lan
YANG Zheng
WANG Qiang
SONG Qiang
CHEN Yong
HUANG Qian
NIE Huan
CHEN Ji-an-min
Abstract：Objective To observe the effect of Ginkgo biloba extract (EGb) on intestinal function after spinal cord injury (SCI) in rats. Methods 36 Sprague-Dawley rats were randomly divided into group A (n=12), group B (n=12) and group C (n=12). SCI model was estab-lished with Allen's mode (10 g × 25 mm) at T10. 30 minutes later, group A was intraperitoneally injected with methylprednisolone 30 mg/kg every 24 hours;group B was injected with Shuxuening injection (EGb) 1.75 mg/kg every 24 hours;group C were injected with equal vol-ume of saline. The slow wave of intestinal smooth muscle was measured, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in serum were determined 1 day, 3 days and 7 days after modeling, while intestinal tissue was tested with HE stain-ing. Results The amplitude and frequency of the myoelectric slow wave increased in the groups A and B 3 and 7 days after modeling com-pared with those in the group C (P<0.05);meanwhile, the activity of SOD increased and content of MDA decreased in the groups A and B (P<0.05). The HE scores decreased in the groups A and B compared with those in the group C (P<0.05), which presented that the inflamma-tory exudation was mild, the hemorrhagic spot was few and the area was limited. The intestinal villous of the group C was blunt with large infiltration of inflammatory cells and inflammatory exudate on the mucosal surface. Conclusion EGb can improve the recovery of intestinal function in rats spinal cord injury through antioxidant.
Keywords：Ginkgo biloba extractspinal cord injurymalondialdehydesuperoxide dismutasegastrointestinal dysfunction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 397-401 )