Effects of Learning Environment on Learning and Memory and Microvessel Density in Hippocampus of Rats after Cerebral Infarc-tion
MA Xiang-yang
ZHANG Li-ping
DONG Jing
HUANG Dong-dong
LIU Dong-mei
SUN Ru-zhi
Abstract：Objective To study the effects of learning environment on learning memory and microvessel density in hippocampus of rats after cerebral infarction. Methods 80 Sprague-Dawley rats were coagulated right middle cerebral arteries electrically, and randomly divided into learning envionment (LE) and standard environment (SE) groups. They were tested with Morris Water Maze 7 d and 28 d after opera-tion. The microvessel density in hippocampus was measured with CD34 immunohistochemstry 1, 3, 7, 14 and 28 days after operation. Re-sults The achievement of Morris Water Maze was significantly better in the LE group than in the SE group (P<0.001), while the microvessel density in the hippocampus was more since 7 days after operation (P<0.05). Conclusion The learning environment can promote the angio-genesis and improve the learning and memory function recovery.
Keywords：cerebral infarctionlearning environmentlearning and memorymicrovessel densityrats
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 42-44 )