Effects of Morroniside on Expression of Matrix Metalloproteinases in Peri-infarct Cortex after Cerebral Ischemia-reperfusion in Rats
HOU Hong-li
SUN Fang-ling
AI Hou-xi
ZHANG Li
WANG Wen
Abstract：Objective To study the effects of morroniside on the expression of matrix metalloproteinase (MMP)-2 and MMP-9 in the peri-infarct cortex 3 days after cerebral ischemia-reperfusion. Methods 15 male Sprague-Dawley rats were randomly divided into sham group (n=3), ischemia group (n=3), and morroniside groups (low, medium and high dosage groups, n=3). The middle cerebral artery were oc-cluded for 30 min, and re-perfused. Morroniside was administered intragastrically once a day at dose of 30 mg/kg, 90 mg/kg and 270 mg/kg 3 hours after operation. The expression of MMP-2 and MMP-9 in peri-infarct cortex were detected with immunohistochemistry staining 3 days after operation. Results The expression of MMP-2 and MMP-9 increased in the ischemia group compared with the sham group (P<0.01), and it decreased in all the morroniside groups compared with the ischemia group (P<0.01). Conclusion Morroniside could decrease the expression of MMP-2 and MMP-9 in the peri-infarct cortex 3 days after ischemia, suggesting protecting the function of blood-brain barri-er from ischemia.
Keywords：cerebral ischemia-reperfusionmorronisidematrix metalloproteinase-2matrix metalloproteinase-9rats
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 5-8 )