Advance in Relationship between Tau Protein and Alzheimer's Disease (review)
HU Jiang-ping
GENG Rui
LI Kai-jun
Abstract：Alzheimer's disease is a common neurodegenerative disease. One of the main pathology is neurofibrillary tangles in neurons, in which principal component is the phosphorylation of tau protein. Previous studies focused on senile plaques and Aβlevels. Recent studies indicated that the development of tau protein closely associated with Alzheimer's disease, especially the abnormal phosphorylation. This pa-per reviewed the relationship between tau protein phosphorylation and Alzheimer's disease based on the perspective of protein kinases and phosphatases.
Keywords：Alzheime r's diseasetau proteinphosphorylationneurofibrillary tanglesreview
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1031-1034 )