Effect of Cx43 Protein on Improvement of Learning and Memory Ability Induced by Enriched Environment in Rats with Traumatic Brain Injury
JIANG Shan
LI Ya-na
XIE Hong-ping
WANG Hui-hui
LI Ling
Abstract：Objective To explore the effect of Cx43 protein on improvement of learning and memory ability induced by enriched envi-ronment (EE) in rats with traumatic brain injury (TBI). Methods TBI model was made by fluid percussion injury (FPI) in Sprague-Dawley rats. The TBI rats were divided into EE group (A), standard housing (ST) group (B), Cx43 specific antisense oligonucleotides (Cx43 ASODN)+EE group (C) and scrambled sequence ODN+EE group (D) with 6 rats in each group. Another 6 normal rats were taken as the control group. Groups C and D were given hippocampal microinjection of Cx43-ASODN (2μl/d/rat, 1.5 mmol/L) and ScrbASODN (2μl/d/rat, 1.5 mmol/L) respectively. Morris water maze was used to evaluated the learning and memory ability. Results The latency was longer and the traversing times was less in group B than in the control group (P<0.05). The latency was shorter in group A than in group B (P<0.05), and there was no significant difference between group A and the control group (P>0.05) from the 9th day after injury. The traversing times was more in group A than in group B and there was no significant difference between group A and the control group (P>0.05). The la-tency was longer and the traversing times was less in group C than in group A (P<0.05). Conclusion Cx43 protein may participate in the im-provement of the learning and memory ability induced by EE in rats with TBI.
Keywords：traumatic brain injuryCx43 proteinlearning and memory abilityenriched environmentrats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 924-927 )