Effect of Mouse Nerve Growth Factor on Cognitive Function and Activities of Daily Living in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
GAO Ya-nan
XU Chen
LI Wen-jie
ZHANG Xiao-qiang
LI Xiang
XU Yong-li
CHEN Xue-li
Abstract：Objective To observe the effect of mouse nerve growth factor (mNGF) on cognitive function and activities of daily living (ADL) in patients with delayed encephalopathy after acute carbon monoxide poisoning. Methods 35 patients with delayed encephalopathy after acute carbon monoxide poisoning were randomly divided into treatment group (n=18) and control group (n=18). Both groups accepted hyperbaric oxygen and medication, while the treatment group was injected with mNGF 20 mg a day in addition for 12 weeks. They were as-sessed with Loewenstein Occupational Therapy Cognitive Asessment (LOTCA) and modified Barthel Index (MBI) before and after treat-ment. Results The scores of LOTCA and MBI improved more in the treatment group than in the control group after treatment (P<0.05). Conclusion mNGF can obviously improve cognitive function and ADL for patients with delayed encephalopathy after acute carbon monox-ide poisoning.
Keywords：delayed encephalopathycarbon monoxide poisoningmouse nerve growth factoractivities of daily livingcognitive func-tion
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 870-872 )