Mechanisms of Cognitive Impairment of Duchenne's Muscular Dystrophy (review)
FU Ya
WU Shi-wen
Abstract：Duchenne's muscular dystrophy (DMD) is a common X-linked recessive neuromuscular disorder that associated with a spec-trum of genetically based cognitive and behavioral disabilities. Several mechanisms have been discussed as the cause of cognitive impair-ment in patients with DMD: absence of different dystrophin isoforms, impairments in neurogenesis, changes of synaptic plasticity, blood-brain barrier alterations, brain metabolic differences, cerebellum disfunction, etc.
Keywords：Duchenne's muscular dystrophycognitive impairmentdystrophinsynapseblood-brain barriermetabolismcerebellumreview
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 451-454 )