Effects of Trimetazidine on Cardiac Function and Heart Rate Turbulence in Coronary Heart Disease and Chronic Heart Failure
Abstract：Objective To evaluate the effects of trimetazidine on cardiac function and autonomic function in patients with coronary heart disease and chronic heart failure. Methods 73 patients with coronary heart disease and chronic heart failure were randomly divided into con-trol group (conventional therapy, n=35) and trimetazidine group (conventional therapy plus oral trimetazidine, n=38). All the patients under-went echocardiography for left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVd), and 24-hour Holter electrocardiogram for heart rate turbulence (HRT) indexes, turbulence onset (TO) and turbulence slope (TS) were calculated before and 3 months after treatment. Results 3 months after treatment, LVEF increased, and LVd shrank in both groups (P<0.01). LVEF improved better in the trimetazidine group than in the control group (P<0.001). TO decreased and TS increased in the trimetazidine group (P<0.05). Only TO decreased in the trimetazidine group (P<0.05). TO and TS improved better in the trimetazidine group than in the control group (P<0.05). Conclusion Trimetazidine could improve cardiac function and autonomic function in patients with coronary heart disease and chronic heart failure.
Keywords：coronary heart diseasechronic heart failuretrimetazidineheart rate turbulence
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 382-384 )