Prediction of Combination of High-sensitivity C-reactive Protein and Homocysteine on Short-term Outcomes of Patients with Acute Ischemic Stroke
Abstract：Objective To explore the relationship of high-sensitivity C-reactive protein (Hs-CRP), homocysteine (HCY) levels and the short-term outcome of acute ischemic stroke (AIS). Methods 189 patients with AIS were included. Serum Hs-CRP, HCY levels and Nation-al Institute of Health Stroke Scale (NIHSS) were assessed after admission. Short-term functional outcome was measured by modified Rankin Scale (mRS) 90 d after admission. Results The serum Hs-CRP and HCY levels were significantly higher in AIS patients than in nor-mal controls (P<0.001). Adjusting age and the NIHSS score, Hs-CRP and HCY were independent prognostic markers of functional outcome and death in patients with AIS. In receiver operating characteristic curve (ROC) analysis, the prognostic accuracy of combined model (HCY and Hs-CRP) was higher than that of biomarkers measured alone and the NIHSS score. Conclusion Hs-CRP and HCY are independent pre-dictors of short-term outcome and mortality after AIS. Combined model may provide additional general prognostic information.
Keywords：acute ischemic strokehigh-sensitivity C-reactive proteinhomocysteineprognosisshort-term
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 347-350 )