Effect of β-aescine Sodium on Tumor Necrosis Factorα in Severe Traumatic Brain Injury
Abstract：Objective To study the effect ofβ-aescine sodium on tumor necrosis factorα(TNF-α) in patient with severe traumatic brain injury and the clinical significance. Methods 60 patients with severe traumatic brain injury were divided equally into control group (n=30) and treatment group (n=30), who accepted routine therapy and furtherβ-aescine sodium respectively. The serum TNF-αwas determined before and 1 d, 2 d, 3 d, 5 d and 7 d after treatment. The patients were assessed with Glasgow Outcome Scale (GOS) 3 months after treat-ment. Results There was significant difference of serum TNF-αbetween treatment group and control group since 3 d after treatment (P<0.05). The score of GOS was better in the treatment group than in the control group 3 months after treatment (P<0.05). Conclusionβ-aes-cine sodium is effective on severe traumatic brain injury. Level of TNF-αmay be related with the outcome of patients with severe traumatic brain injury.
Keywords：β-aescine sodiumsevere traumatic brain injurytumor necrosis factorα
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 259-261 )