Effect of Morroniside on Hematocrit Percentage in Rat of Focal Cerebral Ischemia/Reperfusion
Abstract：Objective To investigate the effect of morroniside on hematocrit percentage in a rat model of focal cerebral ischemia/reperfu-sion. Methods After the modified model induced with occlusion of middle cerebral artery (MCAO) with suture embolus, morroniside was administered intragastrically at the dose of 30 mg/kg (n=8), 90 mg/kg (n=8), and 270 mg/kg (n=8) once a day for 7 d. Acetyl salicylic acid (ASA) was used as positive drug (n=8). Hematocrit percentage was measured with automatic blood tester. Results Compared with the sham group, hematocrit percentage of the model group significantly increased (P<0.001), but increased less in those treated with morroniside and ASA (P<0.05). Conclusion Morroniside could inhibit the increase of hematocrit percentage in MCAO rats.
Keywords：morronisidefocal cerebral ischemiahematocrit percentagerats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 230-232 )