Advance in per2 Gene on Circadian Rhythm of Limbic System (review)
Abstract：Per2 gene plays one of the most critical roles of clock gene which modulates circadian rhythm both in the physiological, bio-chemical and behavioral processes of organisms. The distributions of per2 gene include suprachiasmatic nucleus of the hypothalamus, cen-tral nucleus of amygdala, bed nucleus of the stria terminalis, hippocampus and other components of limbic system;it affects the emotional and visceral activities through participating in the system of circadian rhythm. The central per2 gene regulates the hypothalamus-pituitary-adrenal axis through integration of light input, steroid hormones and other neurotransmitters integration, acting on the target organs, and pre-sentes a circadian rhythm of movement. This article reviewed the morphology and biology of per2 gene, and its participation in limbic sys-tem regulating the circadian rhythm of motional and visceral activities.
Keywords：per2 genelimbic systemcircadian rhythmclock genevisceral motilityreview
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 137-141 )