Effects of Low Intensity Treadmill Training on Spatial Learning and Memory and Expression of Glycogen Synthase Kinase-3βin Hippocampus in Mice
LIU Hui-li
ZHAO Gang
Abstract：Objective To investigate the effects of low intensity treadmill training on spatial learning and memory and expression of gly-cogen synthase kinase-3β(GSK-3β) in hippocampus in mice. Methods 24 female C57BL/6J mice of 3 months were assigned into control group (n=12) and exercise group (n=12). They were assessed with Morris Water Maze task 5 months after exercise. The GSK-3βprotein and mRNA expressed in hippocampus were determined 1 week after the task. Results The latency and path length to escape onto the hidden plat-form decreased in the exercise group (P<0.05), while the cross times increased (P<0.05) compared with the control group. The level of GSK-3βmRNA decreased (P<0.05) and ratio of p-GSK-3β-Ser9 to GSK-3βincreased (P<0.05) as well. Conclusion Low intensity treadmill exercise may improve the spatial learning and memory in mice, which may down-regulate the expression and activity of GSK-3β.
Keywords：treadmill exercisespatial learning and memoryglycogen synthase kinase-3βmice
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1016-1019 )