Effects of Octacosanol on Behavioral Impairments and Its Mechanism through Nerve Growth Factor Mediated Pathway in Parkin-sonism Rats Induced with 6-hydroxydopamine
Abstract：Objective To investigate the effects of octacosanol on the behavioral changes and its potential mechanism in 6-hydroxydopa-mine-induced Parkinsonism rats. Methods 6-hydroxydopamine-induced Parkinsonism rats accepted octacosanol orally in the dosage of 17.5 mg/kg (low dose), 35 mg/kg (medium dose) and 70 mg/kg (high dose) for 2 weeks, and then assessed with rotating test and narrow beam test. The apoptosis cells were counted with TUNEL assay, and the expression of nerve growth factor (NGF), precursor of nerve growth fac-tor (proNGF), as well as their receptors were detected with Western blotting. Results The achievement of behavioral tests significantly im-proved after administration of octacosanol (P<0.05), with the decrease of the apoptotic cells, more expression of NGF and its receptors TrkA, and less expression of caspase-3, proNGF and its receptors p75NTR and sortilin, especially at the dosage of 70 mg/kg (P<0.05). Con-clusion Octacosanol may protect the neurol impairment from 6-hydroxydopamine through NGF mediated pathway to decrease the apoptosis.
Keywords：Parkinson's diseasenerve growth factorprecursor of nerve growth factorneuroprotectionapoptosisrats
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1001-1005 )