Research advances on lactylation modification in sepsis-associated acute lung injury
Fu Zishi
Liang Qun
Guo Xiaosheng
Yu Jie
Abstract：Sepsis,a systemic inflammatory response syndrome triggered by infection,often leads to multiple organ dysfunction.Acute lung injury(ALI)is a common and severe complication with high morbidity and mortality.Lactylation modification,an emerging post-translational modification,covalently attaches lactate groups to lysine residues of proteins via enzymatic reactions,modulating diverse cellular processes including gene expression and inflammation.Research indicates that lactylation modification can impact sepsis-induced ALI progression by regulating macrophage polarization,ferroptosis in lung tissue cells,and its interplay with acetylation modifications.These findings suggest that lactylation-related molecules may serve as potential therapeutic targets or diagnostic biomarkers for sepsis-associated ALI.This review synthesizes current research on the role of lactylation modification in the initiation and progression of sepsis-induced ALI,providing a comprehensive overview on its mechanistic involvement and to propose novel directions for optimizing treatment strategies and drug development.
Keywords：Lactylation modificationSepsisAcute lung Iinjury(ALI)Lactate metabolism
Publication Date：2026-02-10
Online Publishing Date：2026-03-18(First online date of this platform, not the publication date of the document)
Pages：5( 127-131 )