Research advances on pyruvate kinase M2 in sepsis-induced cardiomyopathy
Wang Yayun
He Tianpeng
Guo Longfei
Abstract：Sepsis-induced cardiomyopathy(SIC)is a common cardiovascular complication among septic patients,which significantly increases mortality.As a key rate-limiting enzyme in glycolysis,pyruvate kinase M2(PKM2)not only regulates cellular energy metabolism but also participates in multiple pathophysiological processes including inflammation,mitochondrial quality control(MQC),and dysregulated calcium homeostasis.Based on existing research,this review summarizes the biological characteristics of PKM2 and its research advances in SIC,thereby providing novel therapeutic perspectives for sepsis-induced cardiomyopathy.
Keywords：Pyruvate kinase M2Sepsis-induced cardiomyopathyMitochondrial quality controlInflammatory reactionCalcium hemeostasisGlycolysis
Publication Date：2026-01-10
Online Publishing Date：2026-01-29(First online date of this platform, not the publication date of the document)
Pages：6( 41-46 )