Research progress of sepsis-related vascular endothelial dysfunction and treatment strategies
Yu Denghui
Zhu Pingping
Tian Wen
Xu Hongkai
Hu Haifeng
Lian Jianqi
Abstract：Vascular endothelial dysfunction plays a crucial role in the pathogenesis of sepsis.During sepsis,the vascular endothelium undergoes phenotypic and functional changes such as pro-adhesion,pro-inflammation and pro-coagulation,which are interconnected and mutually regulatory.This article provides an overview of the mechanisms and characteristics of sepsis-related vascular endothelial dysfunction,and reviews of both domestic and international research progress on endothelial therapy.The aim is to offer intervention strategies for improving the prognosis of sepsis patients by targeting vascular endothelial dysfunction in sepsis.
Keywords：SepsisVascular endothelial dysfunctionPhenotypePro-adhesionPro-inflammationPro-coagulationTreatment strategy
Publication Date：2025-10-10
Online Publishing Date：2025-11-07(First online date of this platform, not the publication date of the document)
Pages：6( 843-848 )