Research progress on the brain-gut axis in the pathogenesis of sepsis-associated encephalopathy
He Jixing
Zhao Yinzhi
Pei Sitong
Yuan Yuan
Abstract：Sepsis-associated encephalopathy(SAE)is one of the earliest and most common organ dysfunctions in the patients with sepsis,with an incidence of up to 70％.Recent studies have shown that the brain-gut axis plays a key role in the pathogenesis of SAE.This article systematically reviews the regulatory mechanisms of the brain-gut axis-mediated SAE occurrence and development,focuses on the role of the nervous system,endocrine system,immune system and intestinal microbiota in the pathogenesis of SAE,and discusses the therapeutic strategies targeting the brain-gut axis,so as to provide new ideas for the clinical prevention and treatment of SAE.
Keywords：Sepsis-associated encephalopathyBrain-gut axisTreatment strategyNeural pathwayEndocrine pathwayImmune pathwayMetabolic pathway
Publication Date：2025-08-10
Online Publishing Date：2025-09-10(First online date of this platform, not the publication date of the document)
Pages：7( 716-722 )