Research progress in model construction and damage mechanism of fire smoke inhalation-induced acute lung injury
Li Hanchuan
Ren Bohao
Zhao Shuaibo
He Yanbo
Fang Liben
Li Junming
Fang Jingjing
Abstract：Fire accidents pose a significant threat to human health through toxic components released in pyrolytic smoke,with the respiratory system serving as the primary target organ.This exposure frequently induces smoke inhalation-induced acute lung injury(SI-ALI)with a pathophysiological condition characterized by complex mechanism.Recent years,domestic and foreign scholars have witnessed substantial advancements in global research efforts which focuses on establishing standardized animal models and elucidating the underlying pathological mechanisms of SI-ALI.This review provides a systematic synthesis of cutting-edge research advances in the field,with principal emphasis on elucidating standardized methodologies for SI-ALI model establishment and delineating its pathophysiological characteristics in order to provide a more effective theoretical basis and reference for the development of clinical prevention and treatment strategies in SI-ALI.
Keywords：Fire accidentsSmoke inhalation-induced acute lung injuryModel constructionPathophysiological characteristics
Publication Date：2025-08-10
Online Publishing Date：2025-09-10(First online date of this platform, not the publication date of the document)
Pages：6( 703-708 )