Research progress on the role of intestinal microbiota and their metabolites in sepsis-associated acute kidney injury
Wang Yanfei
Fan Wen
Xu Hua
Ren Yuling
Qiao Xiao
Yao Boren
Feng Qingguo
Dou Lin
Abstract：Sepsis is a life-threatening organ dysfunction caused by the host's dysfunctional response to infection.The kidney is among the most commonly affected organs.The occurrence of sepsis-associated acute kidney injury(SA-AKI)is associated with an increased mortality rate among the patients,indicating a poor prognosis.However,its underlying pathogenesis remains unclear.Currently,a number of studies have identified that intestinal microbiota and its metabolites can contribute to the onset and progression of acute kidney injury(AKI)through direct involvement or modulation of signal transduction pathways.However,a comprehensive summary of its mechanism in the development of SA-AKI has yet to be presented.In the context of sepsis,this study aims to systematically elucidate the effects of intestinal microecology and its metabolites on AKI,thereby providing novel insights and references for the study of the pathogenesis of SA-AKI and the formulation of treatment plans.
Keywords：SepsisAcute kidney injuryIntestinal microbiotaMetabolites
Publication Date：2025-07-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 635-640 )