Mechanism and application of methylene blue in septic shock
Wang Jiakai
Tan Ruimin
Yuan Jing
Ge Chen
Zhang Chenxin
Li Lei
Han Xumin
Du Quansheng
Abstract：Sepsis and its severe form,septic shock,are one of the major diseases leading to patients'death in the field of critical care medicine,and the pathogenesis and course of disease development are complex,and there is still a lack of effective treatments.Several studies have revealed that methylene blue(MB)improves hemodynamics and short-term prognosis in septic shock through multiple mechanisms,including inhibiting excessive nitric oxide production,preserving mitochondrial function,modulating inflammasome activation,and activating antioxidant pathways.However,the potential mechanism,long-term efficacy and drug strategy of MB are still insufficient.This article aims to systematically review the pharmacological properties of MB,elucidate its molecular mechanisms of action,evaluate its clinical application prospects in septic shock,enhance the understanding of the therapeutic potential of MB in order to provide ideas for clinical application.
Keywords：Septic shockMethylene blueNitric oxideMitochondriaInflammasomes
Publication Date：2025-06-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 528-533 )