Clinical effect and safety of noninvasive ventilator combined with dapagliflozin in the patients with acute left heart failure

Liu Yazhong; Zhang Yongqiang; Chen Yunxiao; Liu Jingmin; Liu Qianmei; Wang Chao

doi:10.3969/j.issn.1002-1949.2025.06.008

Abstract：Objective To investigate the clinical effect and safety of noninvasive ventilator combined with dapagliflozin in the patients with acute left heart failure.Methods From October 2023 to April 2024,150 patients with acute left heart failure in Baoding First Central Hospital will be randomly divided into two groups,with 75 patients in each group.The control group was treated with conventional anti-heart failure therapy,and the treatment group was treated with noninvasive ventilator combined with dapagliflozin on the basis of conventional treatment.The clinical efficacy,left ventricular end diastolic diameter(LVEDD),cardiac output(CO),stroke volume(SV),ejection fraction(EF),blood oxygen saturation(SaO2),partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),respiratory rate(RR),brain natriuretic peptide(BNP),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),clinical adverse reactions and major cardiovascular adverse events within 3 months after discharge were compared between the two groups.Results The clinical efficacy of the treatment group(96.00％)was significantly better than that of the control group(84.00％)with statistical significance(P＜0.05).After 3 months of treatment,LVEDD,PaCO2,RR,BNP,hs-CRP and IL-6 were lower than those before treatment,CO,SV,EF,SaO2 and PaO2 were higher than those before treatment(all P＜0.05);LVEDD,PaCO2,RR,BNP,hs-CRP and IL-6 in the treatment group were lower than those in the control group,the levels of CO,SV,EF,SaO2 and PaO2 in the treatment group were higher than those in the control group(all P＜0.05).The incidence of major adverse cardiovascular events in the treatment group was 14.47％,while it in the control group was 28.00％.The difference between the two groups was statistically significant(P＜0.05).Conclusions Compared with conventional anti-heart failure treatment,the clinical efficacy of noninvasive ventilator combined with dapagliflozin in the treatment of patients with acute left heart failure is more accurate,and it has more advantages in improving the heart function and respiratory function of patients and reducing cardiovascular adverse events.