Advances in the understanding of cellular endogenous protective mechanisms in wound repair
Qin Qishun
Wang Xingsheng
Wu Jiang
Li Kai
Lu Chao
Peng Pei
Xu Shihong
Qin Yuchen
Abstract：Following trauma,the body undergoes profound internal disturbances,including inflammatory responses,oxidative stress,metabolic dysregulation and cellular injury.In recent years,increasing attention has been paid to the pivotal role of cellular endogenous protective mechanisms in responding to traumatic stress,maintaining homeostasis and promoting tissue repair.This review systematically summarizes the major pathological changes at the cellular level after trauma,with a focus on immune adaptation,mitochondrial homeostasis,autophagic clearance,antioxidant responses,heat shock proteins(HSPs)regulation,and DNA repair mechanisms in damage control and regeneration.Furthermore,the interactive networks among these endogenous pathways and their potential as clinical intervention targets are discussed.Based on the latest research advances,we propose that multi-pathway co-regulation and individualized precision therapy may represent key strategies for future trauma intervention,aiming to provide theoretical support and novel approaches for both basic research and the transformation and application in wound repair.
Keywords：Wound repairEndogenous protective mechanismsOxidative stressAutophagyImmune regulation
Publication Date：2025-06-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：9( 502-510 )