Research progress of syndecan-1 in sepsis
Huang Ziqing
Jiang Xiaoli
Deng Li
Abstract：Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.Treatment options for sepsis have progressed in recent years.However,there are still significant shortcomings at the diagnostic level of the disease,resulting in missed opportunities for early treatment.The seek for biomarkers that enable early diagnosis and prognostic evaluation is critical in sepsis.Glycocalyx degradation is one of the causes of microcirculatory dysfunction in sepsis.Syndecan-1(SDC-1),one of the components of the endothelial glycocalyx layer,is effective in the early recognition of sepsis,determination of disease severity,and prediction of sepsis complications.It is expected to be a new diagnostic target for sepsis by helping to monitor the effectiveness of therapeutic decisions during risk stratification and prognostic evaluation of the patients.The purpose of this article is to summarize the progress of researches related to SDC-1 in sepsis and to provide references for the diagnosis and treatment of sepsis.
Keywords：Syndecan-1SepsisGlycocalyxBiomarkersDiagnosisPrognostic evaluation
Publication Date：2025-03-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 251-256 )