Research progress and prospects of cuproptosis in cerebral ischemia-reperfusion injury
Meng Jia
Huang Liujiao
Abstract：Cuproptosis is a unique and adjustable modality of cell death induced by copper (Cu2+/Cu+) ionophore,which is different from apoptosis,pyroptosis,autophagy and ferroptosis.This article reviews the metabolism of copper ions,the mechanism of cuproptosis,it's effects on cerebral ischemia-reperfusion injury and related possible pathways in order to provide new ideas for the targeted study of cuproptosis to reduce cerebral ischemia-reperfusion injury,and provides new direction for the treatment of stroke in clinical.
Keywords：CuproptosisIschemic strokeCopper metabolismCerebral ischemia-reperfusion injuryReactive oxygen species
Publication Date：2024-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1064-1069 )