Literature interpretation:Guidelines for seizure prophylaxis in adults hospitalized with moderate-severe traumatic brain injury——a clinical practice guideline for health care professionals from the Neurocritical Care Society
Lyu Wenyi
Hou Mengxue
Zhang Linlin
Zhou Jianxin
Abstract：There are great differences in the clinical use of seizure prophylaxis for patients hospitalized with traumatic brain injury (TBI),including the use,duration,and type of prophylactic antiseizure medications (ASMs) .Currently,there are no guidelines available that address the utility of seizure prophylaxis in the patients hospitalized with moderate-severe TBI.In February 2024,the Neurocritical Care Society (NCS) published the Guidelines for seizure prophylaxis in adults hospitalized with moderate-severe TBI:a clinical practice guideline for health care professionals from the Neurocritical Care Society in the journal of Neurocritical Care.The guideline focuses on three clinical questions.The systematic review and meta-analysis,and Grading of Recommendations,Assessment,Development and Evaluation (GRADE) methodology were used to generate recommendations:①Either prophylactic ASMs (initiated during index hospitalization ) or no ASMs could be used in the patients hospitalized with moderate-severe TBI.②If prophylactic ASMs are used in the patients hospitalized with moderate-severe TBI,the NCS guideline panel suggests levetiracetam should be used rather than phenytoin/fosphenytoin for seizure prophylaxis.③If prophylactic ASMs are used in the patients hospitalized with moderate-severe TBI,the NCS guideline panel suggests a short duration of drug usage (≤7 days) versus a longer duration of drug usage (>7 days) .This paper gives a brief interpretation of this guideline.
Keywords：Traumatic brain injuryEpilepsyProphylacticAntiseizure medicationGuidelineLevetiracetamShort durationElectroencephalogram monitoring
Publication Date：2024-12-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1023-1028 )