Research progress of alveolar macrophage autophagy in acute lung injury/acute respiratory distress syndrome
Li Fu
Zhang Zhiming
Zhang Maofu
Huang Bangrong
Qiao Yujie
Shen Yanyun
Qi Yiyan
Feng Zhouli
Li Aiyu
Abstract：Acute lung injury(ALI)/acute respiratory distress syndrome(ARDS)is a clinically critical syndrome with high morbidity and mortality.In recent years,numerous studies have found that cellular autophagy is closely related to ALI/ARDS lung injury.Alveolar macrophage autophagy has an important regulatory role in the course of ALI/ARDS and can effectively intervene in the course of ALI/ARDS.Combined with literature studies,alveolar macrophage autophagy regulation is found to be an important target for alleviating ALI/ARDS,which can effectively reduce lung injury.In this paper,we review the research progress of dual-targeted regulation of alveolar macrophage autophagy in ALI/ARDS with the aim of providing new research ideas and directions for the clinical treatment of ALI/ARDS in the future.
Keywords：Acute lung injury/acute respiratory distress syndrome(ALI/ARDS)Alveolar macrophageAutophagyLung damageRegulatory role
Publication Date：2024-11-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1002-1006 )