Causal relationship between different dietary intake and the risk of myocardial infarction:a two-sample Mendelian randomization study
Shi Jing
Xu Xi
Li Jiamei
Gao Wenyi
He Mengfei
Wang Gang
Abstract：Objective To explore whether there is a causal relationship between different dietary intake and the risk of myocardial infarction.Methods Genome-wide association study(GW AS)data were obtained from international public databases.A total of 33 single nucleotide polymorphisms(SNPs)associated with dietary intake in 8 categories(including drinks,cereals,vegetables and fruits,meat and eggs,dairy products,beans,nuts and salt)were obtained from the UK Biobank.SNPs associated with myocardial infarction were obtained from FinnGen.A two-sample Mendelian randomization(MR)method was used to assess the causal relationship between the exposure factor(dietary intake)and the outcome event(myocardial infarction).Inverse variance weighted was used as the main analysis method,and Cochrane's Q test,MR-Egger regression,MR pleiotropy residual sum and outlier(MR-PRESSO)test were used for sensitivity analysis.Results Dried fruit intake(OR=0.575,95％CI 0.420-0.788,P＜0.001),shellfish intake(OR=0.392,95％CI 0.156-0.987,P=0.047)and cheese intake(OR=0.690,95％CI 0.560-0.850,P＜0.001)showed negative relationship with a risk of myocardial infarction.Conclusions There was a causal relationship of dried fruit intake,shellfish intake and cheese intake with the onset of myocardial infarction,and their increased intake may reduce the risk of mvocardial infarction.
Keywords：Dietary intakeMyocardial infarctionMendelian randomization
Publication Date：2024-11-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 965-971 )