Genetic prediction for a causal relationship of cardiac structure and function with the risk of hip fracture:a bidirectional,two-sample Mendelian randomization study
Chen Xiutian
Yi Yanzi
Jiang Yulai
Zheng Zewei
Zhang Kuo
Zhang Qingwen
Abstract：Objective To study whether there is a causal relationship of cardiac structure and function with hip fracture by Mendelian randomization(MR)method.Methods Based on summary data from the large-scale genome-wide association studies(GWAS),the primary analysis method was inverse variance weighted(IVW)method.Weighted median(WM)and MR-Egger methods were used as supplementary analysis methods to explore the bidirectional causal relationship of heart structure and function with hip fracture.Sensitivity analysis were conducted to test the stability of the results.Results No causal association was found between 12 genetic predisposition to cardiac magnetic resonance imaging(MRI)phenotypes and hip fracture.In reverse MR analysis,there was a causal association of hip fracture with left ventricular stroke volume(β=-0.04,95％CI=-0.08 to-0.00,P=0.032),right ventricular end-diastolic volume(β=-0.03,95％CI=-0.07 to 0.00,P=0.047),right ventricular end-systolic volume(β=-0.04,95％CI=-0.07 to-0.00,P=0.047),rather than other cardiac MRI phenotypes.Conclusions There is lack of a strong evidence to support the causal relationship of cardiac structure and function with hip fracture.In the reverse,hip fracture has been shown at the genetic level to increase the risk of cardiac structural and functional abnormalities.
Keywords：Mendelian randomizationCardiac structure and functionHip fractureCausalityMagnetic resonance imagingPhenotype
Publication Date：2024-09-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 752-759 )