The research progress of the microbiota-gut-brain axis in sepsis-associated encephalopathy
Yierzhati Aizezi
Ren Tong
Liu Xing
Chai Ruifeng
Wang Yi
Yu Xiangyou
Abstract：Sepsis is one of the primary causes of high morbidity and mortality rates worldwide,and remains a significant clinical challenge in modern medicine.Sepsis can lead to various complications,including acute respiratory distress syndrome,hepatic and renal dysfunction,and neurological impairment.Neurological impairment,known as sepsis-associated encephalopathy(SAE),is a major complication of sepsis.The clinical manifestations of SAE include delirium,coma,seizures and focal neurological signs.SAE can cause short-term reversible central nervous system dysfunction and may also adversely affect patients'long-term prognosis.Currently,the exact pathogenesis of SAE remains unclear.However,with ongoing research,the role of the"microbiota-gut-brain axis"(MGBA)in the occurrence,development and outcome of SAE has garnered increasing attention.This review aims to summarize the role and research progress of the MGBA in sepsis-associated encephalopathy.
Keywords：Sepsis-associated encephalopathyMicrobiota-gut-brain axisMicrobiomeFecal microbiota transplantation
Publication Date：2024-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 711-716 )