New insight of the important role and the significance of lactate in sepsis
Liu Hui
Zhu Xiaomei
Yao Yongming
Abstract：As the key biomarker of tissue hypoperfusion,early lactate level and its clearance rate are related closely to the prognosis of sepsis.Recent studies have been demonstrated that lactate appears to be a crucial signal involving in both innate and adaptive immune responses.Lactate is able to induce protein lactylation,which is proved to regulate the function of cytokines through post-translational modification.Newly hot topics are increasing attention to the lactate production and regulation,including non-anoxic increment of lactate,aerobic glycolysis,and important energy substrate.It is necessary to update our knowledge concerning lactate in sepsis.
Keywords：Blood lactateSepsisPost-translational modificationAerobic glycolysisImmune regulation
Publication Date：2024-08-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 668-671 )