Inositol 1,4,5-trisphosphate receptor and its role during shock
Zhang Lixia
Niu Chunyu
Zhao Zigang
Abstract：The inositol 1,4,5-trisphosphate receptor(IP3R)is the one of primary channels responsible for the release of calcium ions(Ca2+)from the endoplasmic reticulum,playing a vital role in maintaining intracellular calcium homeostasis.The imbalance of calcium homeostasis is an important intermediate link of shock-induced organ dysfunction and structural damage,which is a severe pathological process.The imbalance of calcium homeostasis induced by the dysfunction and abnormal expression of IP3 R which participates in the occurrence and progress of various pathological process,this article reviews the advancements of IP3 R construction and regulation,summarizes the role of IP3 R during hemorrhagic shock and septic shock.Basing on this,we hope to provide a theoretical basis for the prevention and treatment of severe shock,and explore new strategies targeting IP3R.
Keywords：Inositol 145-trisphosphate receptorCalcium homeostasisEndoplasmic reticulum stressHemorrhagic shockSeptic shock
Publication Date：2024-07-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 639-644 )