Changes of serum macrophage migration inhibitory factor in the patients with sepsis complicated with acute lung injury and its influence on the prognosis
Lin Xuerong
Wang Jia
Guo Zhanmin
Zhang Zhibin
Abstract：Objective To study the changes of serum macrophage migration inhibitory factor(MIF)in the patients with sepsis complicated with acute lung injury(ALI)and its effect on the prognosis.Methods A total of 180 patients with sepsis admitted to the First Affiliated Hospital of Hebei North University from May 2021 to December 2023 were selected and divided into ALI group(n=82)and non-ALI group(n=98)according to whether ALI occurred.The differences of serum MIF and various clinical data between the two groups were compared.The influencing factors of sepsis complicated with ALI,and the diagnostic value of each influencing factor in sepsis complicated with ALI were analyzed,the difference of survival prognosis in sepsis complicated with ALI patients with different serum MIF levels were compared.Results The acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)score,sequential organ failure assessment,D-dimer,blood urea nitrogen and MIF of ALI group were higher than those of the non-ALI group(P＜0.05).Multivariate Logistic regression analysis showed that APACHE Ⅱ score and serum MIF were the influencing factors of sepsis complicated with ALI(P＜0.05).The receiver operating characteristic(ROC)curve analysis showed that serum MIF alone and MIF combined with APACHE Ⅱ score were effective in diagnosing sepsis complicated with ALI and the sensitivity and the specificity of combined diagnosis were 90.24％and 88.78％.Kaplan-Meier survival curve analysis showed that increased serum MIF was associated with decreased survival rate in sepsis complicated with ALI patients(P＜0.05).Conclusions The increase of serum MIF level is associated with the occurrence and poor survival prognosis of sepsis complicated with ALI.Serum MIF combined with APACHE Ⅱ score has certain diagnostic value for sepsis complicated with ALI patients.
Keywords：SepsisAcute lung injuryMacrophage migration inhibitory factorAcute physiology and chronic health evaluation ⅡDiagnosisPrognosis
Publication Date：2024-07-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 617-621 )