The clinical manifestations of 32 cases with mushroom poisoning in Jiangsu province based on toxicological testing

Liu Wen; Li Jinquan; Zhou Yu; Xie Weiran; Mao Zhengsheng; Sun Hao

doi:10.3969/j.issn.1002-1949.2024.07.004

Abstract：Objective To investigate the practical significance of toxicological testing technology in the clinical diagnosis and management of mushroom poisoning,and to analyze the clinical manifestations of the patients with confirmed mushroom poisoning in Jiangsu province.Methods This study was a retrospective cohort study conducted at multiple centers.The outcomes of toxicological testing,exposure details and clinical features were collected in 32 patients with mushroom poisoning who underwent toxicological testing and identification in a total of 10 hospitals located in Jiangsu province,which participated in the cohort study from June 2020 to July 2023.The clinical symptoms of the patients with positive toxicological tests were analyzed,and the correlation between toxicological sampling and test outcomes was analyzed.Results A total of 32 clinically diagnosed patients with mushroom poisoning or suspected poisoning were included in this study for toxicological testing.A total of 32 blood samples,31 urine samples,22 mushroom samples,and 1 vomit sample were collected from 32 patients.Among them,18 mushroom samples were positive in toxicological test,accounting for 59.38％,8 types of toxins including α-amanitin toxin were detected in 18 mushroom samples;nicotine was detected in one vomit sample;common toxins were not detected in the blood and urine samples of all the patients.Conclusions Identifying mushroom toxins through toxicological testing can assist in the diagnosis of mushroom poisoning,which helps to more quickly and accurately determine the type of mushroom and the type of toxin it contains,and is convenient for guiding clinical treatment.