The relationship between the critical bleeding volume and clinical prognosis in the patients with supratentorial deep spontaneous intracerebral hemorrhage
Gu Tenghui
Li Li
Gao Juanjuan
Qian Weijun
Abstract：Objective To explore the relationship between the critical value of bleeding volume and clinical prognosis in the patients with supratentorial deep spontaneous intracerebral hemorrhage(sICH).Methods A retrospective analysis was conducted on the clinical data of 300 patients with supratentorial deep sICH registered in the neurology database of Kaifeng Central Hospital from September 2021 to September 2023.The prognosis of the patients was evaluated according to the modified Rankin Scale(mRS)score at 30 days after neurological treatment,and the patients were divided into good prognosis group(n =135)and poor prognosis group(n =165).The patients were further divided into the subgroups based on the site of cerebral hemorrhage,and the relationship between the site of hemorrhage and clinical prognosis in supratentorial deep sICH patients was observed.Receiver operating characteristic(ROC)curve was drawn to determine the optimal critical value for predicting clinical adverse outcomes of different supratentorial deep bleeding sites.The prediction performance was verified by 10-fold cross-validation method.The optimal critical value of bleeding volume was used to verify its relationship with the prognosis.Results Logistic regression analysis indicated the location of sICH was associated with the prognosis of patients with supratentorial deep sICH(P<0.05).ROC analysis showed that the sensitivity and specificity of predicting poor prognosis were higher when the basal ganglia hemorrhage volume was 18.5 mL and the thalamus hemorrhage volume was 8.5 mL.The average AUC of 10-fold cross-validation of hemorrhage volume in different sICH sites of the supratentorial deep region were 0.872 and 0.885,respectively,which further confirmed that the robustness of hemorrhage volume prediction was good.According to the critical value of bleeding volume,bleeding volume was divided into high bleeding volume and low bleeding volume.Logistic regression analysis showed that regardless of adjusting for related confounding factors,the critical values of bleeding volume in different sites were still related to the prognosis of patients with supratentorial deep sICH(P<0.05).Conclusions There is a certain relationship between the location of bleeding and clinical prognosis in the patients with supratentorial deep sICH.The article provided the references for the evaluation of clinical prognosis,active intervention,and precise treatment by analyzing the bleeding volume of basal ganglia at different sites.
Keywords：Supratentorial deep spontaneous intracerebral hemorrhageCerebral bleeding volumeCritical valueBasal gangliaThalamus
Publication Date：2024-05-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 402-407 )